氯丁二烯主要应用于氯丁橡胶的生产,职业接触是主要的暴露途径,可以通过吸入和皮肤吸收进入体内。氯丁二烯在细胞色素P450作用下,氧化代谢为环氧化物,该类环氧化物有致癌性,并通过进一步水解和GSH加合作用,生成一系列水溶性的和易排出的水解化合物和GSH加合物。本文主要综述了有关氯丁二烯代谢的研究,识别其主要代谢产物,为进一步研究职业接触氯丁二烯生物标志物奠定基础。 Chloroprene is mainly used in the production of neoprene, occupational exposure is the main route of exposure, which can be absorbed into the body through inhalation and skin absorption. Chloroprene is oxidatively metabolized to epoxide under the action of cytochrome P450, which is carcinogenic and generates a series of water-soluble and excreted hydrolyzable compounds by further hydrolysis and GSH addition GSH adduct. This review summarizes the studies on the metabolism of chloroprene and identifies its major metabolites, which lays the foundation for further research on occupational exposure to chloroprene biomarkers.