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目的讨论固体脂质纳米粒的制备方法的研究进展。方法通过分析、整理和归纳近几年的国内外文献,介绍固体脂质纳米粒的常用的制备方法、载体材料、存在的不足及改进方法。结果与结论固体脂质纳米粒制备方法多种多样并日趋成熟,所存在的问题已逐渐被解决,该种制剂极具发展前景。
Objective To discuss the research progress of the preparation of solid lipid nanoparticles. Methods By analyzing, sorting and summarizing domestic and foreign literatures in recent years, the commonly used preparation methods of solid lipid nanoparticles, carrier materials, existing problems and the improved methods were introduced. RESULTS AND CONCLUSIONS The preparation methods of solid lipid nanoparticles are diverse and maturing. The existing problems have been gradually solved. This preparation has great potential for development.