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含补骨脂素(Psoralens)的植物用于皮肤病治疗已有几千年历史。植物补骨脂种子浸膏在公元前1400年即被印度人用来医治白癜风。另一种含8-甲氧基补骨脂素(8-MOP)与5-甲氧基补骨脂素(5-MOP)的植物Ammi maivs也在埃及作为药用流行几个世纪。美国从1951年开始使用8-MOP,1964年后使用
Psoralens containing plants have been used for dermatological treatments for thousands of years. Plant psoralen seed extract was used by Indians to treat vitiligo in 1400 BC. Another plant Ammi maivs containing 8-methoxy psoralen (8-MOP) and 5-methoxypsoralen (5-MOP) is also in medicinal endeavors in Egypt for centuries. The United States started using 8-MOP from 1951 and was used after 1964