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目的:检测溃疡性结肠炎患者血清降钙素原的浓度并分析其临床意义。方法:选取该院收治的123例结直肠癌住院患者,依据内镜下病变活动状态的不同,分为缓解组(31例)和发作组(92例),依据病情及严重程度,将发作组患者分为重度组(31例)、中度组(30例)、轻度组(31例),对照组为我院30例同期健康体检者,对所有研究对象行血常规及降钙素原检测并进行统计学分析。结果:①发作组、缓解组、对照组患者的中性粒细胞计数、血清降钙素原水平的差异显著(P均<0.05);发作组患者中性粒细胞计数、血清降钙素原水平高于缓解组及对照组(P均<0.05);缓解组患者的血清降钙素原水平高于对照组(P<0.05),缓解组和对照组患者中性粒细胞计数接近(P>0.05)。②轻度组、中度组、重度组患者的中性粒细胞计数、血清降钙素原水平的差异显著(P均<0.05);重度组患者中性粒细胞计数、血清降钙素原水平高于中度组及轻度组(P均<0.05);中度组患者中性粒细胞计数、血清降钙素原水平高于轻度组(P均<0.05)。结论:血清降钙素原能反应溃疡性结肠炎病情活动状态及严重程度,可考虑普及应用。
Objective: To detect the concentration of procalcitonin in patients with ulcerative colitis and analyze its clinical significance. Methods: A total of 123 patients with colorectal cancer hospitalized in this hospital were enrolled and divided into remission group (n = 31) and seizure group (n = 92) according to the different endoscopic active lesions. According to the severity and severity, The patients were divided into severe group (31 cases), moderate group (30 cases) and mild group (31 cases). The control group was 30 healthy people in our hospital at the same period. All the subjects underwent routine blood tests and procalcitonin Testing and statistical analysis. Results: ①The difference of neutrophil count and serum procalcitonin level between the attack group, the remission group and the control group was significant (all P <0.05); the neutrophil count, serum procalcitonin level (P <0.05). The level of procalcitonin in patients in remission group was higher than that in control group (P <0.05), neutrophil count in remission group and control group was close (P> 0.05 ). (2) There were significant differences in neutrophil count and serum procalcitonin level between mild group, moderate group and severe group (all P <0.05); neutrophil count, serum procalcitonin level (P <0.05). The neutrophil count and serum procalcitonin level in moderate group were higher than those in mild group (all P <0.05). Conclusion: Serum procalcitonin reactive ulcerative colitis activity status and severity, can be considered universal application.