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目的:观察经肝动脉自体骨髓干细胞移植治疗失代偿期肝硬化的临床疗效。方法:失代偿期肝硬化患者50例,分别采集患者骨髓200mL。从中分离纯化的骨髓干细胞经肝动脉移植至患者肝脏。比较患者术前术后症状、体征、肝功能和凝血指标。结果:自体骨髓干细胞移植第1个月后,35例(70%)患者症状得到明显改善。术后47例(94%)患者停止使用利尿剂后未再出现腹水。术后血清白蛋白、总胆红素、Child-Pugh评分较术前明显改善(P<0.05)。术后凝血酶原时间和纤维蛋白原接近正常值。结论:经肝动脉自体骨髓干细胞移植治疗失代偿期肝硬化可在短时间内提高血清白蛋白,改善肝功能。
Objective: To observe the clinical effect of autologous transplantation of autologous bone marrow stem cells for the treatment of decompensated cirrhosis. Methods: 50 patients with decompensated cirrhosis were collected in patients with bone marrow 200mL. The isolated and purified bone marrow stem cells were transplanted to the liver of patients via hepatic artery. Preoperative and postoperative symptoms, signs, liver function and coagulation index were compared. Results: After the first month of autologous bone marrow stem cell transplantation, the symptoms of 35 patients (70%) were significantly improved. Forty-seven patients (94%) had no recurrence of ascites after stopping their use of diuretics. Postoperative serum albumin, total bilirubin, Child-Pugh score was significantly improved compared with preoperative (P <0.05). Postoperative prothrombin time and fibrinogen near normal values. Conclusion: Transplantation of autologous bone marrow stem cells via hepatic artery in the treatment of decompensated cirrhosis can increase serum albumin and improve liver function in a short time.