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目的:探讨宫颈癌的现患率并分析其相关危险因素。方法:回顾分析确诊为宫颈癌的患者65例和随机选取的114例确诊未发生宫颈鳞状上皮内瘤变的健康妇女的相关资料,并对其进行问卷调查及相关检查,对各指标行单因素和多因素非条件Logistic回归分析。结果:宫颈癌现患率为240/10万。单因素分析发现,与宫颈癌发生有关的是人乳头瘤病毒(HPV)感染(P<0.01)、血清硒(Se)含量<1.06μg/ml(P<0.01),患宫颈炎年限>2年(P<0.01)、性伴侣>3个(P<0.05)、避孕套防护(P<0.01),多因素非条件Logistic分析发现宫颈癌发病主要危险因素依次是HPV感染(P<0.01)、血清Se含量<1.06μg/ml(P<0.01)。结论:宫颈癌现患率处在相对较高的水平,HPV感染、血清Se含量低与宫颈癌的发生有很大关联,因此预防HPV感染,补充微量元素Se对控制女性宫颈癌会起到积极作用。
Objective: To explore the prevalence of cervical cancer and analyze the related risk factors. Methods: A retrospective analysis of 65 patients diagnosed as cervical cancer and 114 randomly selected healthy women without cervical squamous intraepithelial neoplasia related information, and its questionnaire survey and related tests, the indicators of a single line Factors and Multivariate Non-conditional Logistic Regression Analysis. Results: The prevalence of cervical cancer was 240 / 100,000. Univariate analysis showed that the incidence of cervical cancer was HPV infection (P <0.01), selenium (Se) content was less than 1.06μg / ml (P <0.01), and the duration of cervicitis was> 2 years (P <0.01), sexual partners> 3 (P <0.05) and condom protection (P <0.01) .Multivariable unconditional Logistic analysis showed that the main risk factors of cervical cancer were HPV infection (P <0.01), serum Se content <1.06 μg / ml (P <0.01). Conclusion: The prevalence of cervical cancer is at a relatively high level. HPV infection and low serum Se levels are closely related to the occurrence of cervical cancer. Therefore, the prevention of HPV infection and the supplementation of trace element Se play an active role in the control of female cervical cancer .