从植物中提取的天然化合物由于其无毒性和抗肿瘤活性而受到科学界的广泛关注.异甘草素(Isoliquiritigenin,ISL)是从甘草(Glycyrrhiza uralensis)根部提取的一种黄酮类活性化合物,已被证明具有明确的抗炎、抗氧化和抗肿瘤作用.在过去几年中,针对ISL抗肿瘤作用的研究数量逐渐增加.目前研究发现,ISL主要通过阻滞细胞周期、诱导细胞凋亡和自噬等方式抑制肿瘤细胞活力、细胞增殖及迁移.然而,其抗肿瘤作用的确切分子机理尚不完全清晰.这篇综述主要针对ISL抗肿瘤的生物学效应和分子机制进行全面概述.“,”Natural compounds derived from plants have attracted considerable attention in the scientific community due to their nontoxic nature and anti-cancer activity.Isoliquiritigenin (ISL),an active flavonoid isolated from the root of the licorice plant (Glycyrrhiza uralensis),has been previously demonstrated to have anti-inflammatory,antioxidant and tumor suppressive effects.In the past few years,the number of studies describing the effects of ISL against cancer has been gradually increased.ISL has been found to inhibit viability,proliferation,and migration of cancer cells mainly through cell cycle arrest,induction of apoptosis as well as autophagy.However,the molecular mechanisms of action are not completely comprehended.This review aimed to provide a comprehensive summary of the biological effects and molecular mechanisms of ISL against cancer.