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目的探讨多种肿瘤标志物蛋白芯片检测系统对胰腺癌的诊断价值及意义。方法所有病人均抽取空腹静脉血2ml送检,严格按照蛋白芯片检测仪的使用说明进行检测。结果胰腺癌病人的单项标志物以CA19-9阳性率最高,其次为CA242、CEA和Fer,而NSE、F-PSA、PSA、HGH、CA15-3的阳性率极低,甚至为零;胰腺癌病人的综合阳性率为87.5%,而慢性胰腺炎病人的综合阳性率仅为22.22%,两组比较差异有显著性。结论多肿瘤标志物的检测对胰腺癌的诊断具有重要价值,但检测NSE、F-PSA、PSA、HGH、CA15-3的意义甚微;综合分析几种标志物的检测结果,较任何单一标志物的阳性率更高;推测在高危年龄段人群,常规进行CA19-9、CA242、CEA、Fer检测,将有助于胰腺癌的早期发现。
Objective To investigate the diagnostic value and significance of a variety of tumor marker protein chip detection system for pancreatic cancer. Methods All patients were taken fasting venous blood 2ml submission, in strict accordance with the instructions of the protein chip detector for testing. Results The positive rates of CA19-9, CA242, CEA and Fer were highest in single markers of pancreatic cancer patients, and the positive rates of NSE, F-PSA, PSA, HGH and CA15-3 were extremely low or even zero. The comprehensive positive rate of patients was 87.5%, while the comprehensive positive rate of patients with chronic pancreatitis was only 22.22%, the difference between the two groups was significant. Conclusion The detection of multiple tumor markers is of great value in the diagnosis of pancreatic cancer. However, the detection of NSE, F-PSA, PSA, HGH and CA15-3 is of little significance. The results of several markers comprehensively compared with those of any single marker The higher the positive rate, the higher the positive rate. It is speculated that routine detection of CA19-9, CA242, CEA and Fer in high-risk age groups will be helpful for the early detection of pancreatic cancer.