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目的 研究血栓调节蛋白 (TM)在胃癌组织中的表达。方法 应用免疫组织化学ABC法对 40例手术切除胃癌标本进行TM表达的研究。结果 18例肠型胃癌中 ,15例TM表达阳性(83.3% ) ,2 2例弥漫型胃癌中 ,11例TM表达阳性 (5 0 .0 % ) ;6 0岁以上病人 2 3例 ,其中 19例TM表达阳性 (82 .6 % ) ,6 0岁以下病人 17例 ,其中 7例TM表达阳性 (41.2 % )。肠型胃癌TM的表达明显高于弥漫型胃癌 (P <0 .0 5 ) ;6 0岁以上病人胃癌组织TM的表达显著高于 6 0岁以下的病人 (P <0 .0 5 )。结论 肠型胃癌TM的表达显著高于弥漫型胃癌。
Objective To study the expression of thrombomodulin (TM) in gastric cancer. Methods Immunohistochemical ABC method 40 cases of surgical resection of gastric cancer specimens for TM expression study. Results Among the 18 cases of intestinal type gastric cancer, 15 cases were positive for TM (83.3%), and of the 2 2 cases of diffuse gastric carcinoma, 11 cases were positive for TM (50.0%), and 23 cases were over 60 years old Cases TM positive expression (82.6%), 17 cases of patients under 60 years of age, of which 7 cases of TM expression was positive (41.2%). The expression of TM in intestinal-type gastric cancer was significantly higher than that in diffuse-type gastric cancer (P <0.05). The expression of TM in gastric cancer was significantly higher in patients over 60 years old than in patients under 60 (P <0.05). Conclusion The expression of TM in intestinal type gastric cancer is significantly higher than that in diffuse type gastric cancer.