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目的探讨新疆地区维吾尔族、汉族心房颤动(AF)患者心房颤动的发生与血清尿酸水平的关系。方法以维吾尔族、汉族心房颤动患者各100例作为病例组,以维吾尔族、汉族非心房颤动患者各100例作为对照组,记录各组患者的年龄、性别、尿酸水平,用药情况等。采用Logistic回归分析心房颤动发生的危险因素。结果维吾尔族、汉族病例组与对照组比较,年龄、低密度脂蛋白、总胆固醇、尿酸水平差异有统计学意义(P<0.05),心房颤动组年龄、低密度脂蛋白、总胆固醇和尿酸均显著高于非心房颤动组。多因素Logistic回归分析结果发现,年龄(OR=1.114,95%CI=1.080~1.149,P<0.01)、总胆固醇(OR=1.902,95%CI=1.434~2.522,P<0.01)和尿酸(OR=1.023,95%CI=1.017~1.029,P<0.01)是心房颤动的独立危险因素。结论在新疆地区维吾尔族和汉族人群中,血清尿酸可能是心房颤动的危险因素。
Objective To investigate the relationship between atrial fibrillation and serum uric acid in Uygur and Han nationality patients with atrial fibrillation (AF) in Xinjiang region. Methods A total of 100 patients with atrial fibrillation in Uygur and Han nationality were enrolled in this study. 100 Uyghur and Han non-atrial fibrillation patients were enrolled as control group. The age, sex, uric acid level and medication were recorded. Logistic regression was used to analyze the risk factors of atrial fibrillation. Results Compared with the control group, the age, low density lipoprotein, total cholesterol, and uric acid in the Uygur and Han cases were significantly different (P <0.05). The age, LDL, total cholesterol and uric acid in the atrial fibrillation group were significantly higher than those in the control group Significantly higher than non-atrial fibrillation group. Multivariate logistic regression analysis showed that the total cholesterol (OR = 1.902, 95% CI = 1.434-2.522, P <0.01) and uric acid (OR) = 1.023, 95% CI = 1.017 ~ 1.029, P <0.01) was an independent risk factor for atrial fibrillation. Conclusions Serum uric acid may be a risk factor of atrial fibrillation among Uighur and Han people in Xinjiang region.