手指和手的弥漫性皮肤硬化、关节活动受限是系统性硬皮病的特征性症状。近年亦知糖尿病患者也有相同的变化,病因也相似。作者报告1例43岁男性患者,28岁时诊断为糖尿病,37岁眼底出血,40岁出现肾脏损害,42岁因肾功能不全始行血液透析。半年前出现两手明显僵硬、无雷诺氏现象。查见皮肤变化局限两手,手指均呈浮肿性硬化,不能伸直,不能紧密对掌。皮肤弥漫性硬化、肥厚、活动受限,未见皮肤色素异常和毛细血管扩张。初诊时高度怀疑系统性硬皮病,但发病后2年半中未发现可以诊 Diffuse sclerosis of the fingers and hands, restricted joint activity is a characteristic symptom of systemic scleroderma. In recent years, diabetic patients also know the same changes, the causes are similar. The authors report a 43-year-old male patient diagnosed with diabetes at age 28, hemorrhage at the age of 37, retinopathy at age 40, and hemodialysis at 42 years due to renal insufficiency. Six months ago, his hands were obviously stiff and there was no Raynaud’s phenomenon. Check see the skin changes both hands, fingers were edema, can not be straight, not close to the palm. Diffuse skin sclerosis, hypertrophy, limited mobility, no skin pigmentary dysfunction and telangiectasia. High initial suspicion of systemic scleroderma, but not found in 2 and a half years after onset can be diagnosed