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目的:观察中西医结合治疗不稳定型心绞痛的临床疗效。方法:将210例气虚血瘀型不稳定型心绞痛患者随机平均分为3组各70例,3组患者入院后均采用常规的治疗方法,心痛逐瘀汤组口服中药心痛逐瘀汤,氯吡格雷片组口服氯吡格雷片,联合治疗组给予前2个治疗方案联合治疗,疗程均为3周。于3周治疗结束后对患者进行疗效评估,观察心电图情况,测定血小板聚集率和血栓素B2的水平。结果:联合治疗组的症状疗效、心电图疗效总有效率均高于氯吡格雷片组、心痛逐瘀汤组(P<0.05),氯吡格雷片组2项疗效总有效率均高于心痛逐瘀汤组(P<0.05)。治疗后,3组的血小板聚集率和血栓素B2均较治疗前明显下降(P<0.05),联合治疗组血小板聚集率和血栓素B2的降低程度均优于氯吡格雷片组与心痛逐瘀汤组(P<0.05),氯吡格雷片组与心痛逐瘀汤组相比,差异均无统计学意义(P>0.05)。结论:中西医结合治疗气虚血瘀型不稳定型心绞痛,可以抑制血小板的聚集,减少心绞痛的发作次数,并对心功能有改善作用。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of unstable angina pectoris. Methods: A total of 210 cases of unstable angina pectoris with Qi-deficiency and blood stasis type were randomly divided into three groups of 70 cases. All the three groups were treated by conventional methods after treatment. Xintongzhuyu Decoction group was given oral Xintongzhuyu Decoction, Gram tablets oral clopidogrel tablets, combined treatment group given the first two treatment regimens combined treatment, treatment were 3 weeks. The curative effect of the patients was evaluated after 3 weeks of treatment, the electrocardiogram was observed, and the platelet aggregation rate and the level of thromboxane B2 were measured. Results: The curative effect and the total effective rate of electrocardiogram in combination therapy group were higher than that in clopidogrel group and Xintongzhuyu Decoction group (P <0.05). The total effective rate of two curative effect of clopidogrel group was higher than that of heartache Yu group (P <0.05). After treatment, the platelet aggregation rate and thromboxane B2 in three groups were significantly lower than those before treatment (P <0.05). The platelet aggregation rate and thromboxane B2 reduction in combination group were better than those in clopidogrel group (P <0.05). There was no significant difference between clopidogrel tablet group and Xintongzhuyu Decoction group (P> 0.05). Conclusion: The combination of TCM and WM treatment of unstable angina pectoris of Qi deficiency and blood stasis can inhibit platelet aggregation, reduce the number of angina attacks, and improve cardiac function.