目的:探讨老年人脉压和脉压指数与代谢综合征及其组分的相关性和剂量反应关系。方法:横断面研究，选择2019年武进区65岁及以上健康体检老年人114 212例，代谢综合征患者40 388(35.4%)。调查内容包括问卷调查、体格检查和实验室检查。采用Logistic回归和限制性立方样条分析脉压和脉压指数与代谢综合征患病的相关性和剂量反应关系。结果:随脉压水平和脉压指数的增加，代谢综合征及其各组分的患病率逐渐增加(n P<0.01)。调整混杂因素后，代谢综合征的n OR值随脉压和脉压指数的增加逐渐升高，与最低四分位比较，脉压在第二、三和四组相关(n OR＝1.52，95%n CI：1.47～1.58；n OR＝1.89，95%n CI：1.82～1.96；n OR＝2.15，95%n CI：2.07～2.23)；脉压指数与第二、三和四组相关(n OR＝1.22，95%n CI：1.18～1.26；n OR＝1.36，95%n CI：1.31～1.41；n OR＝1.47，95%n CI：1.42～1.53)。限制性立方样条分析结果显示，脉压和脉压指数与代谢综合征呈非线性剂量反应关系(n χ2值分别为309.23和57.14，均n P<0.01)。n 结论:脉压和脉压指数与老年人代谢综合征及其组分相关，且呈现非线性剂量反应关系。“,”Objective:To investigate the correlation and dose-response relationship of pulse pressure and pulse pressure index with metabolic syndrome in the elderly population.Methods:This was a cross-sectional study.A total of 114 212 subjects aged 65 years and over in Wujin District receiving health examination in 2019 were enrolled, including 40 388(35.4%)patients with metabolic syndrome.The survey contents included a questionnaire, physical examination and laboratory tests.Logistic regression and restricted cubic splines were used to analyze the correlation and dose-response relationship of pulse pressure and pulse pressure index with metabolic syndrome.Results:With increases in pulse pressure levels and pulse pressure index, the prevalence of metabolic syndrome and its components increased accordingly(n P<0.01). After adjusting for confounding factors, then ORvalue of metabolic syndrome gradually increased along with increases in pulse pressure and pulse pressure index.Compared with the first quartile, pulse pressure and pulse pressure index in the second, third and fourth quartiles were correlated with metabolic syndrome(pulse pressure: n OR=1.52, 95%n CI: 1.47~1.58, n OR=1.89, 95%n CI: 1.82~1.96 and n OR=2.15, 95%n CI: 2.07~2.23, respectively; pulse pressure index: n OR=1.22, 95%n CI: 1.18~1.26, n OR=1.36, 95%n CI: 1.31~1.41 andn OR=1.47, 95%n CI: 1.42~1.53, respectively). Restricted cubic spline analysis showed that pulse pressure and pulse pressure index had non-linear dose-response relationships with metabolic syndrome(n χ2=309.23 and 57.14, n P<0.01).n Conclusions:Pulse pressure and pulse pressure index are correlated and show non-linear dose-response relationships with metabolic syndrome and its components in the elderly.