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目的了解住院患者鲍曼不动杆菌感染的临床分布及耐药性变迁,为合理应用抗菌药物提供依据。方法通过对某医院临床感染患者送检病原学标本的检测,了解鲍曼不动杆菌感染的临床分布和耐药性状况。结果该医院每年从临床分离的鲍曼不动杆菌株数,由2006年的12株增加到2013年的72株;每年检出的鲍曼不动杆菌感染病人有50%以上来自重症监护病房。临床分离鲍曼不动杆菌对头孢类抗菌药物耐药率从2006年的50%以下,增加到2013年的94%以上;对碳青霉烯类抗菌药物耐药率从2006年0,增加到2013年的60%以上。结论该医院住院病人鲍曼不动杆菌感染及耐药率均呈现逐年增加趋势,感染患者主要分布于重症监护病房,应加强监测,采取有效干预措施。
Objective To understand the clinical distribution and drug resistance changes of Acinetobacter baumannii inpatients, so as to provide basis for rational use of antimicrobial drugs. Methods To detect the clinical distribution and drug resistance of Acinetobacter baumannii infection by detecting the etiological specimens of clinically infected patients in a hospital. Results The number of clinically isolated Acinetobacter baumannii strains per year increased from 12 in 2006 to 72 in 2013. More than 50% of the Acinetobacter baumannii infections were detected each year in the ICU. Clinical isolates of Acinetobacter baumannii to cephalosporins antimicrobial resistance rate from 50% in 2006 to 94% in 2013 increased; carbapenem antibiotic resistance rates from 2006 to 0, increased to More than 60% in 2013. Conclusions Acinetobacter baumannii infection rate and drug resistance rate of inpatients in this hospital are increasing year by year. Infected patients are mainly distributed in intensive care unit and should be monitored intensively and effective intervention measures taken.