登革病毒引起的疾病在世界范围内的流行、暴发日益频繁 ,出现登革出血热及登革休克综合征的病例数亦呈显著的上升趋势 ,目前虽然对其发病机理尚不明了 ,但越来越多的研究表明病毒的毒力及宿主的抵抗力因素起着重要作用。在病毒的进化过程中 ,某些核苷酸的变异会导致病毒毒力的变化 ,出现强毒株或减毒株 :它们侵入宿主后 ,若宿主能使病毒的合成速率减慢 ,可降低发生病毒血症的可能性。本文主要对这两方面的研究进展作一综述。 Dengue virus-related diseases worldwide prevalence outbreaks are more frequent, the number of cases of dengue haemorrhagic fever and dengue shock syndrome also showed a significant upward trend, although the pathogenesis is not yet understood, but the more More and more studies have shown that virulence of the virus and the host’s resistance factors play an important role. Variations in certain nucleotides can lead to a change in the virulence of a virus during its evolution, producing either virulent strains or attenuated strains: they reduce the rate of virus synthesis if they invade the host Viremia possibility. This article mainly summarizes the research progress in these two aspects.