为探讨中西医结合治疗溃疡病穿孔的机理及其对胃肠激素的影响 ,对 2 8例患者作治疗前后胃动素(MTC)、胃泌素 (Gastrin)、表皮生长因子 (EGF)放免检查。结果 :非手术治疗成功者中Gastrin、MTC明显降低(P <0 0 1 ) ,EGF明显升高 (P <0 0 1 ) ;中转手术者MTC和EGF无明显变化 (P >0 0 5) ,而Gastrin反下降 (P <0 0 1 )。认为中西医结合治疗溃疡病穿孔可能是通过神经—内分泌—细胞网络来实现的。 To explore the mechanism of traditional Chinese and western medicine in the treatment of perforation of ulcer disease and its effect on gastrointestinal hormones, 28 patients were treated with radioimmunoassay (MTC), gastrin (EGF) and epidermal growth factor (EGF) . Results: Gastrin and MTC were significantly lower in non-surgical patients (P <0.01), EGF was significantly higher (P <0.01), MTC and EGF in patients who underwent transcranial surgery were not significantly different (P> 0.05) Gastrin inversely decreased (P <0.01). That traditional Chinese and Western medicine treatment of ulcer perforation may be through the neuroendocrine - cell network to achieve.