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目的 测定国产维库溴铵的量 -效关系并与进口维库溴铵进行比较。方法 将120例择期手术病人随机分为国产维库溴铵组 (60例 )及进口维库溴铵组 (60例 ) ,两组各分为6个剂量组 ,每个剂量组10例 ,分别注射维库溴铵10μg/kg、20μg/kg、30μg/kg、40μg/kg、50μg/kg、100μg/kg。使用加速度肌松监测仪以四个成串刺激观察拇收肌颤搐反应 ,当第一个颤搐反应达最大阻滞时即为肌松效应 ,同时记录起效时间。 结果 国产维库溴铵ED5 、ED50 、ED95分别为10.11μg/kg、20.45μg/kg、41.38μg/kg,与进口维库溴铵组比较差别均无显著性意义 (均P>0.05)。结论 国产维库溴铵的量 -效关系及肌松效应与进口维库溴铵相似。
Objective To determine the quantity-response relationship of domestic vecuronium and to compare with imported vecuronium. Methods 120 cases of elective surgery were randomly divided into domestic vecuronium group (60 cases) and vecuronium group (60 cases). The two groups were divided into 6 dose groups, 10 cases in each dose group, respectively Vecuronium bromide 10μg / kg, 20μg / kg, 30μg / kg, 40μg / kg, 50μg / kg, 100μg / kg were injected. Muscle relaxation effects were observed when the first twitch response reached maximal block using an accelerated muscle relaxant monitor with four series of stimuli to observe the twitch response of the adductor muscle, while the onset time was recorded. Results The mean values of ED5, ED50 and ED95 of domestic vecuronium bromide were 10.11μg / kg, 20.45μg / kg and 41.38μg / kg respectively. There was no significant difference between the two groups (P> 0.05). Conclusion The dose-effect relationship and muscle relaxation effect of domestic vecuronium are similar to those of imported vecuronium.