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目的探讨神经节苷脂联合胞二磷胆碱治疗新生儿缺氧缺血性脑病的临床效果。方法选取确诊为新生儿缺氧缺血性脑病的患儿60例,随机分为对照组和观察组,每组各30例,两组均行常规“三维持”“三对症”治疗,对照组在常规治疗的基础上加用胞二磷胆碱治疗,观察组在对照组的基础上,加用神经节苷脂钠,比较两种不同治疗方法的效果及不良反应发生情况。结果对照组总有效率53.3%。观察组总有效率93.3%。两组总有效率经统计学分析,差异有统计学意义(P<0.05)。两组治疗过程中均未见明显不良反应发生。结论本研究采用神经节苷脂联合胞二磷胆碱治疗新生儿缺氧缺血性脑病,临床效果效果显著,副作用少,使用方便,适于临床推广。
Objective To investigate the clinical effect of ganglioside combined with citicoline on neonatal hypoxic-ischemic encephalopathy. Methods Sixty children diagnosed with neonatal hypoxic-ischemic encephalopathy were randomly divided into control group and observation group, with 30 cases in each group. All patients underwent routine “three-dimensional” The patients in the control group were treated with citicoline on the basis of conventional treatment. The patients in the observation group were treated with ganglioside sodium on the basis of the control group, and the effects of two different treatment methods and the occurrence of adverse reactions were compared. Results The control group, the total effective rate was 53.3%. Observation group, the total effective rate 93.3%. The total effective rate of the two groups by statistical analysis, the difference was statistically significant (P <0.05). No significant adverse reactions occurred in both groups during the course of treatment. Conclusion In this study, ganglioside combined citicoline treatment of neonatal hypoxic-ischemic encephalopathy, the clinical effect of significant effect, less side effects, easy to use, suitable for clinical promotion.