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目的观察分析雷贝拉唑治疗幽门螺杆菌(Hp)阴性胃溃疡(GU)的临床疗效。方法收集120例Hp阴性的胃溃疡患者,随机分为两组,观察组接受雷贝拉唑治疗,而对照组接受雷尼替丁治疗。治疗4周后观察临床症状情况,并通过胃镜检查,观察溃疡愈合,并比较胃窦部炎症情况。结果经4周治疗后,发现观察组患者临床症状(如上腹部疼痛、上腹不适、嗳气)得到明显控制,溃疡愈合率明显高于对照组(P<0.05),胃窦部炎症分级也明显降低(P<0.05)。结论雷贝拉唑可有效地缓解Hp阴性GU症状,加强GU愈合,是治疗GU的一种有效方法。
Objective To investigate the clinical efficacy of rabeprazole in the treatment of Helicobacter pylori (Hp) -negative gastric ulcer (GU). Methods A total of 120 Hp-negative gastric ulcer patients were collected and randomly divided into two groups. The observation group received rabeprazole, while the control group received ranitidine. After 4 weeks of treatment, the clinical symptoms were observed. Gastroscopy was used to observe the ulcer heal, and the inflammation of gastric antrum was compared. Results After 4 weeks of treatment, the clinical symptoms (such as upper abdominal pain, abdominal discomfort and belching) in the observation group were significantly controlled, the healing rate of ulcer was significantly higher than that of the control group (P <0.05), and the inflammation grade of gastric antrum was also significantly decreased (P <0.05). Conclusion Rabeprazole can effectively alleviate the symptoms of Hp-negative GU and strengthen the healing of GU. It is an effective method to treat GU.