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目的研究分析尿激酶溶栓治疗急性心肌梗死过程中心电图及心肌酶(CK、CK-MB)的变化与临床意义。方法对136例急性心肌梗死发病时间在12 h以内的患者给予尿激酶(UK)150万U溶栓治疗,每30 min行心电图检查,每2 h查心肌酶,并严密观察患者的临床表现。结果 90例患者于溶栓治疗后2 h出现胸痛明显缓解和各种心律失常,CK-MB峰值出现于8 h;10例患者在4 h出现胸痛缓解和各种心律失常,CK-MB峰值出现于12 h;36例患者则于6 h后仍无任何改变,为溶栓治疗无效者。结论尿激酶溶栓治疗急性心肌梗死临床疗效显著,方法安全可靠,操作简便,值得在临床上推广应用。
Objective To study the changes and clinical significance of electrocardiogram and myocardial enzyme (CK, CK-MB) in the treatment of acute myocardial infarction with urokinase thrombolysis. Methods One hundred and sixty-five patients with acute myocardial infarction within 12 hours after onset of thrombolytic therapy were given thrombolytic therapy with 1.5 million U.Under electrocardiogram every 30 minutes, myocardial enzymes were examined every 2 hours and the clinical manifestations were closely monitored. Results In 90 patients, 2 hours after thrombolytic therapy, chest pain was significantly relieved and all kinds of arrhythmia were observed. The peak value of CK-MB appeared at 8 hours. In 10 cases, chest pain relief and various arrhythmia occurred at 4 hours, and CK-MB peak appeared At 12 h, 36 patients had no change after 6 h, and were ineffective in thrombolytic therapy. Conclusion Urokinase thrombolytic therapy of acute myocardial infarction clinical efficacy is significant, the method is safe and reliable, easy to operate, it is worth in the clinical application.