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目的防止或延缓主药自氧化变质,保证注射液的有效性和稳定性。方法通过测定维生素C氧化情况,提示“自氧化反应”对药物的影响及不同抗氧剂的抗氧作用。结果抗氧化能力:NaHSO3>Na2S2O3>NaS2O5。结论影响维生素C稳定性主要因素是空气中的氧和溶液的pH值。在pH值一定时,当抗氧剂与药物同时存在,空气中的氧首先与抗氧剂发生作用,从而保持了药物的稳定性。另外,微量的金属离子对自动氧化反应有显著催化作用。
Objective To prevent or delay self-oxidation of the main drug metamorphism, to ensure the effectiveness and stability of injection. Methods by measuring the oxidation of vitamin C, suggesting “autoxidation ” on the impact of drugs and different antioxidants antioxidant. Results Antioxidant capacity: NaHSO3> Na2S2O3> NaS2O5. Conclusion The main factors influencing the stability of vitamin C are the oxygen in the air and the pH value of the solution. At a certain pH, when the antioxidant and the drug coexist, the oxygen in the air first interacts with the antioxidant to maintain the stability of the drug. In addition, trace amounts of metal ions have a significant catalytic effect on auto-oxidation.