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目的:探讨高压氧(HBO)联合美沙拉秦灌肠治疗放射性肠炎的临床疗效。方法:选取2017年6月至2019年12月东南大学医学院附属江阴医院普外科收治的放射性肠炎患者43例。根据治疗方式分为联合组(23例)和对照组(20例)。对照组患者在常规治疗基础上给予美沙拉秦灌肠治疗，联合组患者在对照组治疗基础上予以HBO治疗。治疗前后分别采用国际放疗远期并发症评分标准(LENT-SOMA)、肠镜检查评估患者的损伤程度，生命质量测定量表(QLQ-C30)评价患者的生命质量。结果:与治疗前相比，治疗后2组患者的症状积分及总积分较治疗前均明显下降，联合组患者治疗后症状积分及总积分较对照组明显降低，差异均有统计学意义(n P<0.05)。2组患者治疗后肠镜下黏膜糜烂、血管扩张、溃疡出血的情况明显好转，联合组患者治疗后肠镜下病情改善程度较对照组明显，差异均有统计学意义(n P<0.05)。对照组患者治疗后总有效率为60.0%，联合组总有效率为87.0%，差异有统计学意义(n P<0.05)。QLQ-C30评估发现，治疗后联合组患者情绪功能较对照组显著提高，而疼痛、失眠、便秘、腹泻因子得分较对照组显著下降，差异均有统计学意义(n P<0.05)。n 结论:HBO联合美沙拉秦灌肠治疗放射性肠炎疗效更为显著，可提高患者的生命质量。“,”Objective:To investigate the clinical effect of hyperbaric oxygen (HBO) therapy combined with mesalazine enema in the treatment of radiation enteritis.Methods:Forty-three eligible patients with radiation enteritis admitted to Jiangyin People’s Hospital Affiliated to the School of Medicine of Southeast University between June 2017 and December 2019 were selected and randomly divided into combined group (23 cases) and control group (20 cases) according to the methods of treatment. All the patients were given conventional treatment. Then, the patients in the control group received mesalazine enema, while those in the combined group received HBO on the basis of the treatments of the control group. Before and after treatment, the late effects normal tissues-subjective, objective, management, and analytic (LENT-SOMA) scales and enteroscopy were used to evaluate the degree of lesion, and Quality of Life Questionnaire-Core Questionnaire (QLQ-C30) was used to evaluate the patients’ quality of life.Results:After treatment, the symptom score and total score of both groups were significantly lowered, moreover, the two scores of the combined group were significantly lower than those of the control group (n P<0.05). Compared with before treatment, the degrees of mucosal erosion, vasodilation, and ulcer bleeding under enteroscopy in both groups were significantly improved, and the improvement in the combined group was significantly better than that in the control group (n P<0.05). The total effective rate was 60.0% in the control group and 87.0% in the combined group, with statistically significant difference (n P<0.05). QLQ-C30 evaluation suggested that, after treatment, the emotional function of the patients in the combined group was significantly better than that of the patients in the control group, while the scores of pain, insomnia, constipation, and diarrhea factors of the combined group were significantly lower than those in the control group (n P<0.05).n Conclusion:HBO combined with mesalazine enema is more effective in the treatment of radiation enteritis, and it can improve the quality of life of patients.