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研究海马内输注白细胞介素６（ＩＬ６）对大鼠主动躲避反应的影响和一氧化氮参与该过程的可能机制．方法：使用穿梭箱模型，在海马内输注ＩＬ６和硝普钠（ＳＮＰ）后ｄ８开始进行行为实验．使用荧光测定方法，检测海马内输注ＩＬ６后２４ｈ时海马的亚硝酸盐水平．结果：ＩＬ６３２ｎｇ对获得和保留均无影响．ＩＬ６１６ｎｇ和８０ｎｇ显著延长了训练躲避潜伏期，从而损害了主动躲避反应的获得，但对其保留无影响．ＳＮＰ４００ｎｇ和ＩＬ６８０ｎｇ通过减少躲避反应率也损害了主动躲避反应的获得，而对保留无影响．ＩＬ６８０ｎｇ显著升高了海马亚硝酸盐水平，而ＩＬ６３２ｎｇ对之无影响．结论：ＩＬ６海马内输注损害大鼠主动躲避反应．
To study the effect of transfusion of interleukin-6 (IL-6) in hippocampus on spontaneous evasion in rats and the possible mechanism of nitric oxide involved in this process. METHODS: Using a shuttle box model, behavioral experiments were started at d8 after infusion of IL-6 and sodium nitroprusside (SNP) in the hippocampus. Fluorescence assay was used to detect hippocampal nitrite levels in hippocampus 24h after transfusion of IL6. Results: IL 632ng had no effect on access and retention. IL 616ng and 80ng significantly prolonged the training escape latency, thus undermining the acquisition of active avoidance response, but had no effect on its retention. SNP400ng and IL 680ng also reduced the avoidance response rate also undermined the acquisition of active avoidance response, and had no effect on the retention. IL 680ng significantly increased hippocampal nitrite levels, while IL 632ng no effect. Conclusion: Intra-hippocampal IL 6 impaired rats actively evading the reaction.