Tumor necrosis factor receptor-associated factor (TRAF) proteins are conserved in higher eukaryotes and play key roles in transducing cellular signals across different organelles.They are characterized by their C-terminal region(TRAF-C domain) containing seven to eight anti-parallel β-sheets,also known as the meprin and TRAF-C homology (MATH) domain.Over the past few decades,significant progress has been made toward understanding the diverse roles of TRAF proteins in mammals and plants.Compared to other eukaryotic species,the Ara-bidopsis thaliana and rice (Oryza sativa) ge-nomes encode many more TRAF/MATH domain-containing proteins;these plant proteins cluster into five classes:TRAF/MATH-only,MATH-BPM,MATH-UBP (ubiquitin protease),Seven in ab-sentia (SINA),and MATH-Filament and MATH-PEARLI-4 proteins,suggesting parallel evolution of TRAF proteins in plants.Increasing evidence now indicates that plant TRAF proteins form central signaling networks essential for multiple biological processes,such as vegetative and reproductive development,autophagosome formation,plant immunity,symbiosis,phyto-hormone signaling,and abiotic stress responses.Here,we summarize recent ad-vances and highlight future prospects for un-derstanding on the molecular mechanisms by which TRAF proteins act in plant development and stress responses.