利用研磨法制备氨苯砜海藻酸钠固体分散体,后将含有氨苯砜的海藻酸钠混悬液滴加至氯化钙溶液中制得氨苯砜海藻酸钙微球。通过X-射线衍射(XRD)和差示扫描量热法(DSC)考察药物及辅料的分散状态,光学显微镜(OM)观察微球的表面形态,反相高效液相色谱法(RP-HPLC)测定微球的包封率、载药量,并考察微球在水介质中的释放行为。结果表明,所制备微球粒径均小于1 mm,且药物以无定型状态分散于微球中。体外释放实验表明,微球具有较好的缓释效果,体外释放完全需要32 h。 The solid dispersion of dapsone sodium alginate was prepared by the grinding method, and then the sodium alginate suspension containing dapsone was added dropwise to the calcium chloride solution to prepare dapsone calcium alginate microspheres. The dispersion status of drugs and excipients was investigated by X-ray diffraction (XRD) and differential scanning calorimetry (DSC). The surface morphology of microspheres was observed by optical microscope (OM) The entrapment efficiency and drug loading of the microspheres were measured, and the release behavior of microspheres in aqueous media was also investigated. The results showed that the prepared microspheres were less than 1 mm in diameter, and the drug was dispersed in the microspheres in an amorphous state. In vitro release experiments showed that the microspheres have a good sustained release effect, in vitro release completely takes 32 h.