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人参(GR)具有降血糖作用,本次探讨了GR对肝糖转运载体(GLUT2)的影响。①GR的降血糖作用:给予GR的水提取物(200、400mg/kg,po)4h后明显降低正常及肾上腺素诱发的高血糖小鼠(EP小鼠)的血糖值,但正常小鼠的血糖值降低程度小,②对GLUT2的影响:用蛋白质印迹法进行探讨,与非给药组比较,GR的水提取物(200mg/kg)组,使正常及EP小鼠的GLUT2蛋白质表达明显增加。因此认为GR降血糖作用机制与GLUT2的增加有关。
Ginseng (GR) has a hypoglycemic effect. This study investigated the effect of GR on the glycogen transporter (GLUT2). Hypoglycemic effect of 1GR: After administration of GR water extract (200, 400 mg/kg, po) for 4 h, blood glucose levels of normal and epinephrine-induced hyperglycemic mice (EP mice) were significantly decreased, but normal mice were given blood glucose. The degree of decrease in the value was small, and the effect of 2 on GLUT2 was investigated by Western blotting. Compared with the non-administration group, the GR water extract (200 mg/kg) group significantly increased GLUT2 protein expression in normal and EP mice. Therefore, it is considered that the mechanism of lowering blood glucose in GR is related to the increase of GLUT2.