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为探讨ＣＴＬ－Ｆａｓ－ＦａｓＬ系统在急慢性乙型肝病中的作用，本文采用免疫组化法对１１０例急慢性乙型肝病组织中的Ｆａｓ抗原和ＦａｓＬ的表达进行了检测。结果Ｆａｓ和ＦａｓＬ的表达率急性乙肝分别为５５．３％和６０．５％、慢性乙肝８７．０％和８４．８％、肝硬化８０．０％和７０．０％、慢重乙肝１００％和１００％（Ｐ＜０．０５）；慢性乙肝其肝组织Ｆａｓ和ＦａｓＬ的表达强度与患者的年龄、性别和血清ＡＬＴ水平无关，而与血清Ａ、Ａ／Ｇ、ＰＴＡ和ＴＢＩＬ水平有关。结果表明，由ＣＴＬ－Ｆａｓ－ＦａｓＬ系统介导的肝细胞凋亡，在急慢性乙型肝病的发病机制中起了重要的作用
In order to investigate the role of CTL-Fas-FasL system in acute and chronic hepatitis B, the expression of Fas antigen and FasL in 110 cases of acute and chronic hepatitis B were detected by immunohistochemistry. Results The positive rates of Fas and FasL were 55.3% and 60.5% for acute hepatitis B, 87.0% and 84.8% for chronic hepatitis B, 80.0% and 70.0% for cirrhosis, 100% And 100% respectively (P <0.05). The expression of Fas and FasL in the liver of patients with chronic hepatitis B was not correlated with the age, sex and serum ALT level of the patients with chronic hepatitis B, but with the serum levels of A, A / G, PTA and TBIL. The results show that the apoptosis of hepatocytes mediated by CTL-Fas-FasL system plays an important role in the pathogenesis of acute and chronic hepatitis B