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目的观察复方贞术调脂胶囊对兔实验性动脉粥样硬化(AS)的影响。方法取50只家兔分为对照组,模型组,辛伐他汀(3mg/kg)组,复方贞术调脂胶囊高、低剂量(生药1.6、0.8g/kg)组,每组10只。采用高脂饮食法建立兔AS模型,药物组在喂高脂饲料的同时每天给予相应的药物,连续喂养12周。实验末,检测血清脂质、载脂蛋白水平、主动脉组织中总胆固醇(TC)和甘油三酯(TG)水平以及主动脉内膜斑块面积比,观察主动脉病理形态学变化。结果复方贞术调脂胶囊组血清TC、TG、低密度脂蛋白-胆固醇(LDL-C)、动脉粥样硬化指数(AI)及载脂蛋白-B(ApoB)水平较模型组显著降低(P<0.05、0.01),高密度脂蛋白-胆固醇(HDL-C)水平和载脂蛋白A1/载脂蛋白B(ApoA1/ApoB)值显著升高(P<0.05);ApoA1水平有升高趋势,但差异无统计学意义(P>0.05);主动脉组织中的脂质的量以及内膜斑块面积比显著低于模型组(P<0.05、0.01)。光镜下观察结果显示,各给药组主动脉病变程度均明显减轻。结论复方贞术调脂胶囊具有抑制实验性动脉粥样硬化形成的作用,可能与其调节脂质代谢作用有关。
Objective To observe the effect of Fufang Zhenzhu Tiaozhi Capsule on experimental atherosclerosis (AS) in rabbits. Methods Fifty rabbits were randomly divided into control group, model group, simvastatin (3mg / kg) group, high and low dose (1.6,0.8g / kg crude drug group), 10 rats in each group. Rabbit AS model was established by high-fat diet. The drug group was fed with high-fat diet and the corresponding drugs were given daily for 12 weeks. At the end of the experiment, serum lipid, apolipoprotein level, total cholesterol (TC) and triglyceride (TG) level in the aorta tissue and plaque area ratio in the aorta were detected to observe the pathological changes of the aorta. Results The levels of serum TC, TG, LDL-C, AI and ApoB in Fufang Zhenju Tiaozhi Capsule group were significantly lower than those in model group (P (P <0.05). The levels of HDL-C and ApoA1 / ApoB were significantly increased (P <0.05); the level of ApoA1 was increased, But the difference was not statistically significant (P> 0.05). The amount of lipid and the area of plaque in the aorta were significantly lower than those in the model group (P <0.05, 0.01). Light microscopic observations showed that the degree of aortic lesion was significantly reduced in each group. Conclusion Fufang Zhenzhu Tiaozhi Capsule can inhibit the formation of experimental atherosclerosis, which may be related to the regulation of lipid metabolism.