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目的观察氟康唑联合阴道局部用药治疗复发性外阴阴道假丝酵母菌病(RVVC)的疗效。方法 RVVC患者60例随机均分为两组,均予乳酸杆菌250mg塞阴道后穹窿,每天1次,连用10d。观察组在治疗第1、4、7天加用氟康唑150mg,每天1次;对照组予制霉菌素栓10万U,每晚塞阴道后穹窿,连用14d。比较两组疗效、不良反应及复发率。结果观察组总有效率高于对照组(93.33%vs.76.67%)(P<0.05)。随访3个月,两组均未出现明显不良反应。对照组复发2例(6.67%);观察组无复发病例。结论氟康唑联合乳酸杆菌治疗RVVC临床疗效好,无明显不良反应。
Objective To observe the efficacy of topical fluconazole combined with vaginal treatment of recurrent vulvovaginal candidiasis (RVVC). Methods Sixty patients with RVVC were randomly divided into two groups. All patients were given Lactobacillus 250mg into the vaginal fornix once daily for 10 days. The observation group was treated with fluconazole 150mg once daily on the 1st, 4th and 7th day of treatment. The control group was given Nystatin suppository with a volume of 100,000 U, which was inserted into the vaginal fornix every night for 14 days. The curative effect, adverse reaction and relapse rate of the two groups were compared. Results The total effective rate in observation group was higher than that in control group (93.33% vs.76.67%) (P <0.05). Follow-up 3 months, no significant adverse reactions in both groups. The control group relapsed in 2 cases (6.67%); no recurrence in the observation group. Conclusion Fluconazole combined with Lactobacillus treatment of RVVC good clinical efficacy, no significant adverse reactions.