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[目的]分析CoxAl6引起某幼儿园手足口病暴发的特征。[方法]对幼儿园儿童进行流行病学和临床特征的调查;并采集典型病例粪便、急性期与恢复期血液标本,密切接触者粪便标本进行肠道病毒分离或/和PCR检测,血清中和抗体测定。[结果]发病25例,罹患率9.8%,用RD和Vero细胞自8份患儿和35份密切接触者粪便标本中各分离到3株和9株病毒,对3例病例及10例密切接触者中分离株,诊断为柯萨奇病毒A16型,而EV 71型均为阴性。血清中和抗体测定恢复期中和抗体滴度呈4倍及以上增长。[结论]CoxAl6肠道病毒是导致本次幼儿园手足口病暴发的病原,今后应加强肠道病毒引起的手足口病的监测和防治研究工作。
[Objective] To analyze the characteristics of CoxAl6 caused by hand-foot-mouth disease in a kindergarten. [Methods] The epidemiological and clinical features of kindergarten children were surveyed. The blood samples of typical cases, blood samples of acute phase and convalescent phase were collected, and the stool specimens of close contacts were isolated for virus or / and PCR. Serum neutralizing antibody Determination. [Results] The incidence of 25 cases, the attack rate of 9.8%, with RD and Vero cells from 8 children and 35 close contacts of stool specimens of each isolated 3 and 9 strains of virus in 3 cases and 10 cases of close contact Among the isolates, Coxsackievirus A16 was diagnosed, whereas EV 71 was negative. Serum neutralizing antibody assay showed a 4-fold and above neutralizing antibody titers during recovery. [Conclusion] The CoxAl6 enterovirus is the causative agent of hand-foot-mouth disease in this kindergarten. In the future, the surveillance and prevention and treatment of hand-foot-mouth disease caused by enterovirus should be strengthened.