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采用放射免疫法，对１８例急性心肌梗塞（ＡＭＩ）后血浆平均内皮素（ＥＴ）、肾素活性（ＰＲＡ）、血管紧张素Ⅱ（ＡⅡ）、心钠素（ＡＮＰ）浓度变化进行动态观察，并以同期健康成人作对照。结果显示，ＡＭＩ后血浆平均ＥＴ值明显升高（Ｐ＜０．００１），２４小时内升高最显著（７４．２３ｐｇ／ｍｌ，Ｐ＜０．００１），２周后逐渐恢复正常。Ｋｉｌｌｉｐ分级Ⅰ～Ⅳ中ＥＴ值均有明显升高（３７．３８ｐｇ／ｍｌ，Ｐ＜０．００２；４９．１ｐｇ／ｍｌ，Ｐ＜０．００１；５５．８５ｐｇ／ｍｌ，Ｐ＜０．００１；２０４ｐｇ／ｍｌ，Ｐ＜０．００１）。ＥＴ与ＰＲＡ、ＡⅡ、ＡＮＰ的变化具有相关性，相关系数（ｒ）分别为０．８６、０．８４、０．６７。说明ＡＭＩ后血浆ＥＴ浓度升高，其升高幅度与心功能状态有关，ＥＴ与其它内分泌激素的相关关系证实了ＥＴ的内分泌功能及心脑－内皮反馈机制在ＡＭＩ发病机理中起到了重要作用。
Radioimmunoassay was used to observe the change of plasma endothelin (ET), renin activity (PRA), angiotensin Ⅱ (Ⅱ) and atrial natriuretic peptide (ANP) in 18 patients with acute myocardial infarction And healthy adults for the same period as a control. The results showed that after AMI, the average ET value in plasma increased significantly (P <0.001), and the most significant increase in 24 hours (74.23pg / ml, P <0.001). After 2 weeks, the mean ET gradually returned to normal. ET values in Killip grading Ⅰ ~ Ⅳ were significantly increased (37.38pg / ml, P <0.002; 49.1pg / ml, P <0.001; 55.85pg / ml, P <0.001; 204 pg / ml, P <0.001). ET and PRA, A Ⅱ, ANP changes have correlation, correlation coefficient (r) were 0.86,0.84,0.67. Explain that after AMI, the concentration of ET in the plasma increases, and its increase amplitude is related to the state of cardiac function. The correlation between ET and other endocrine hormones confirms that the endocrine function of ET and the cardiocerebral-endothelial feedback mechanism play an important role in the pathogenesis of AMI.