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目的：探讨血清胱抑素C、尿酸与缺血性脑血管病患者颈动脉粥样硬化的关系。方法选择缺血性脑血管病患者250例，应用彩色多普勒超声检查患者颈动脉内-中膜厚度（IMT），综合评估患者颈动脉粥样硬化程度及斑块性质。选择同期250名年龄和性别相匹配的健康体检者作为对照组，观察两组之间胱抑素C、尿酸的差异。运用逻辑回归分析方法分析血清胱抑素C、尿酸对缺血性脑血管病患者颈动脉粥样硬化的作用。结果①病例组血清胱抑素C值[1.00（0.21）μmol/L]显著高于对照组[0.92（0.17）μmol/L]，病例组尿酸值[300（85.25）μmol/L]显著高于对照组[286（94.25）μmol/L]，差异均有统计学意义（均P0.05）。③多元逻辑回归分析显示，胱抑素C水平升高是颈动脉粥样斑块形成的独立危险因素（OR=1.052，95%CI：1.029-1.075）。结论①血清胱抑素C、尿酸水平升高是发生缺血性脑血管病的重要危险因素；②血清胱抑素C升高与缺血性脑血管病患者颈动脉粥样硬化的形成及发展密切相关，检测血清胱抑素C水平可以反映其颈动脉粥样硬化程度。“,”Objective To investigate the relationship betweenserumcystatin C (Cys-C) ,uric acid (UA) level andcarotid atheroscleroticin patientswith ischemic cerebrovascular disease (ICVD). Methods A total of 250 patients with first-ever ischemic stroke.Color Doppler ultrasound of carotid artery wasused to detect the carotid artery intima-mediathickness (IMT).The degree of CAS in patients was assessed comprehensively.selecting 250 age and sex-matched healthy controls as control group.The Cys-C,UA concentrations indexes were measuredby an enzymatic method and carefully analyzed. Therelationship betweenthe serum Cys-C,UA level and the carotid atherosclerotic plaques were analyzed. Results ①The levels of Cys-C,UA in patients with ischemic cerebrovascular disease was higher than thatof the controlsubjects(P<0.05).②Wefound that the serum Cys-Clevelsinboth IMT thickening and the plaque formation groupswere significantly higher than the normal IMT group (P<0.05).And UA levels of the plaque formation group were significantly higher than the normalIMT group(P<0.05).③Multivariate logistic regression analysisshowed that the increasedCys-C level was an independent risk factor for carotidatherosclerotic plaque formation (OR =1.052,95%CI: 1.029-1.075).Conclusion Cystatin-C, Uric acid are independentrisk factors forischemic cerebrovascular disease.Cys-C is an independentrisk factor for carotid atherosclerotic plaque formationin patients with ischemic cerebrovascular disease.