1临床资料患者女,78岁。外阴结节10余年。10年前患者发现阴阜部出现一蚕豆大褐色结节,逐渐增大,无自觉症状。曾外用多种糖皮质激素药膏、中草药药膏等治疗,疗效不显著。近半年来结节迅速增大,摩擦或搔抓后可破溃出血。既往体健,否认家族遗传病史。体检:一般情况较好,系统体检未见异常。皮肤科情况:阴阜左侧可见一5.0cm×6.0cm大淡红色肿块,上见不规则色素沉着,表面不光滑,可见点状糜烂(图1)。皮损组织 1 Clinical data Female patient, 78 years old. Vulvar nodules more than 10 years. Ten years ago, a large brown nodule was found in the part of the mons pubescent area, gradually increasing without any symptoms. Had a variety of glucocorticoid ointment, herbal ointment and other treatment, the effect is not significant. Nodules in the past six months increased rapidly, friction or scratching bleeding after ulceration. Past physical health, deny the family history of genetic disease. Physical examination: the general situation is better, no abnormal physical examination. Dermatology: the left side of the mons pubis seen a 5.0cm × 6.0cm large red lumps, see the irregular pigmentation, the surface is not smooth, visible erosion point (Figure 1). Skin lesions