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天然RGD肽与其整合素受体介导的细胞与细胞及细胞外基质的粘附是细胞迁移和识别的重要基础和途径 ,与许多生物过程密切相关。目前关于RGD肽的研究已从抗血小板凝聚作用侧重到抑制肿瘤细胞粘附、抗癌细胞转移和抗肿瘤新血管生成等方面。研究证明 ,整合素家族中αυβ3与细胞粘附和新生血管形成的关系最为密切 ,而其配体RGD肽对肿瘤血管内皮细胞的粘附和迁移有明显的抑制作用 ;RGD肽还可诱导肿瘤细胞中caspase 3和caspase 7表达的增高 ,从而促进肿瘤细胞的凋亡。遗传修饰腺病毒连接上RGD肽 ,可提高对肿瘤细胞的选择性 ,使腺病毒有可能在临床上成为基因治疗的理想载体。RGD肽与肿瘤治疗之间关系的探索为人类彻底根治肿瘤带来了希望 ,是近年来肿瘤治疗研究领域的热点。
Natural RGD peptides and their integrin receptor-mediated cell adhesion to cells and extracellular matrix is an important basis and pathway for cell migration and recognition, and is closely related to many biological processes. The current research on RGD peptides has focused on anti-platelet aggregation to inhibit tumor cell adhesion, anti-cancer cell metastasis and anti-tumor neovascularization. Studies have shown that integrin family αυβ3 and cell adhesion and neovascularization most closely, and its ligand RGD peptide on tumor vascular endothelial cell adhesion and migration significantly inhibited; RGD peptide can also induce tumor cells In caspase 3 and caspase 7 expression increased, thereby promoting tumor cell apoptosis. Genetically modified adenovirus linked to RGD peptide, can improve the selectivity of tumor cells, making adenovirus may become clinically an ideal vector for gene therapy. The exploration of the relationship between RGD peptide and tumor therapy has brought hope for the radical cure of human tumor and is a hot spot in the field of cancer therapy in recent years.