目的综述近年来有关微重力导致骨丢失的最新研究进展。资料来源与选择国内外该领域的相关文献。资料引用资料引用文献40篇。资料综合详细描述了微重力对成骨细胞增殖、分化的影响。着重介绍了微重力对骨髓间质干细胞到成熟成骨细胞整个分化过程的影响及其可能机制。结论微重力不但影响成骨细胞的增殖和活性,也影响骨髓间质干细胞骨向分化过程,导致成熟成骨细胞的数量减少和活性下降,引起空间骨丢失。 Objective To summarize the latest research progress of microgravity induced bone loss in recent years. Sources and selection of relevant literature in this field at home and abroad. References 40 references. Data synthesis describes in detail the effects of microgravity on osteoblast proliferation and differentiation. The effects of microgravity on the whole differentiation process of bone marrow mesenchymal stem cells into mature osteoblasts and its possible mechanism are mainly introduced. Conclusion Microgravity not only affects the proliferation and activity of osteoblasts, but also affects the bone differentiation process of bone marrow mesenchymal stem cells, resulting in the decrease of the number of mature osteoblasts and the decrease of activity, which leads to the loss of spatial bone.