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目的 探讨正常妇女及不同孕期的妊娠妇女的骨超声速率、钙代谢及骨转换的变化特点。 方法 30例正常妇女为对照组 ,130例正常妊娠妇女分为早、中、晚孕组 ,清晨空腹抽血留尿 ,测定胫骨超声速率 ,以骨钙素为骨形成指标 ,尿钙及尿脱氧吡啶啉与肌酐的比值为骨吸收指标 ,并测定血清总钙及游离钙。 结果 妊娠妇女与对照组比 ,胫骨 SOS降低 2 %～3% ,血清总钙降低 5 %～ 8% ,骨钙素 (BGP)呈下降趋势 ,尿钙 / Cr及尿脱氧吡啶啉 / Cr上升明显。 结论 妊娠期骨吸收增加 ,骨形成减少 ,胫骨 SOS下降 ;结合多项指标能更好地反映妊娠期钙代谢的情况 ;增加妊娠期妇女钙的摄入量 ,以期减少骨吸收 ,缓解骨密度的下降。
Objective To investigate the changes of bone ultrasound, calcium metabolism and bone turnover in normal women and pregnant women in different stages of pregnancy. Methods Thirty normal women served as the control group. One hundred and thirty normal pregnant women were divided into early, middle and late pregnancy groups. Blood samples were taken from the abdomen in the morning for fasting urine to determine the tibial ultrasonic rate. Osteocalcin was taken as the bone formation index. Urinary calcium and urine deoxygenated The ratio of pyridine to creatinine was the index of bone resorption, and the total serum calcium and free calcium were measured. Results Compared with the control group, the serum levels of SOS in tibia decreased by 2% -3%, serum total calcium decreased by 5% -8%, BGP decreased, and urinary calcium / Cr and urine deoxypyridyl / Cr increased significantly . Conclusions Increased bone resorption during gestation, reduced bone formation and decreased SOS in tibia, combined with multiple indexes can better reflect the calcium metabolism in pregnancy, and increase calcium intake in pregnant women in order to reduce bone resorption and relieve bone mineral density decline.