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目的分析双重血浆置换(DFPP)治疗肾病综合征(NS)合并高胆固醇血症的临床疗效。方法 40例NS合并高胆固醇血症患者为研究对象,随机分为对照组和实验组,各20例。对照组患者给予阿托伐他汀治疗,实验组患者在对照组基础上行DFPP治疗,随访观察1个月,比较两组治疗前后甘油三脂(TG)、总胆固醇(TC)、血清肌酐(SCr)、白蛋白(ALB)等指标。结果随访1个月,实验组TC(10.8±3.3)mmol/L,与对照组的(13.1±2.5)mmol/L比较差异有统计学意义(P<0.05)。另外,两组随访1个月时TG、SCr、ALB水平比较差异无统计学意义(P>0.05)。结论 DFPP在降低患者高胆固醇血症上有一定的作用,值得临床研究利用。
Objective To analyze the clinical efficacy of double plasmapheresis (DFPP) in the treatment of nephrotic syndrome (NS) combined with hypercholesterolemia. Methods Forty patients with NS and hypercholesterolemia were randomly divided into control group and experimental group, with 20 cases in each group. Patients in the control group were treated with atorvastatin. Patients in the experimental group were treated with DFPP on the basis of the control group, and were followed up for 1 month. The levels of triglyceride (TG), total cholesterol (TC), serum creatinine (SCr) , Albumin (ALB) and other indicators. Results One month follow-up, TC (10.8 ± 3.3) mmol / L in the experimental group was significantly lower than that in the control group (13.1 ± 2.5) mmol / L (P <0.05). In addition, there was no significant difference in TG, SCr and ALB between the two groups at 1 month follow-up (P> 0.05). Conclusion DFPP plays a role in reducing hypercholesterolemia in patients and is worthy of clinical study.