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目的观察左旋卡尼汀治疗对急性心肌梗死患者心功能的影响。方法68例急性心梗患者,随机分成治疗组及对照组,除常规治疗外,治疗组加左旋卡尼汀治疗2周。分别测量心梗后第1周、第4周、第12周患者的左室射血分数(LVEF)以及第4周、第12周患者6min步行试验。结果治疗后第12周两组患者LVEF和6min步行试验结果较治疗前已有明显恢复(P<0．001);而左旋卡尼汀治疗组的患者,较对照组亦提高,差异有显著性(P<0．05)。结论左旋卡尼汀有助于急性心肌梗死患者心功能的恢复。
Objective To observe the effect of L-carnitine on cardiac function in patients with acute myocardial infarction. Methods 68 patients with acute myocardial infarction were randomly divided into treatment group and control group. In addition to conventional treatment, the treatment group plus levocarnitine treatment for 2 weeks. Left ventricular ejection fraction (LVEF) in patients at 1 week, 4 weeks and 12 weeks after myocardial infarction were measured respectively, and 6-minute walking test in 4 weeks and 12 weeks were performed. Results The results of LVEF and 6-min walk test in both groups after treatment showed significant recovery (P <0.001) compared with those before treatment, while those in L-carnitine group were also significantly higher than those in control group (P <0.05). Conclusion L-carnitine is helpful for the recovery of cardiac function in patients with acute myocardial infarction.