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BACKGROUND:Cell therapy has been promising for various diseases.We investigated whether transplantation of human umbilical cord mesenchymal stem cells(h UCMSCs)has any therapeutic effects on D-galactosamine/lipopolysaccharide(Gal N/LPS)-induced fulminant hepatic failure in mice.METHODS:h UCMSCs isolated from human umbilical cord were cultured and transplanted via the tail vein into severe combined immune deficiency mice with Gal N/LPS-induced fulminant hepatic failure.After transplantation,the localization and differentiation of h UCMSCs in the injured livers
BACKGROUND: Cell therapy has been promising for various diseases. We investigated whether transplantation of human umbilical cord mesenchymal stem cells (h UCMSCs) has any therapeutic effects on D-galactosamine / lipopolysaccharide (Gal N / LPS) -induced fulminant hepatic failure in mice. METHODS: h UCMSCs isolated from human umbilical cord were cultured and transplanted via the tail vein into severe combined immune deficiency mice with Gal N / LPS-induced fulminant hepatic failure. After transplantation, the localization and differentiation of h UCMSCs in the injured livers