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本文报告肾综合征出血热Ⅱ型地鼠肾细胞灭活疫苗在山东省高发人群接种后的免疫效果。疫苗初免３针后２周、１２个月血清中和抗体阳转率分别为６８．９６％（２０／２９）、１８．５％（５／２７），１２个月复种１针后血清中和抗体阳转率达１００％（２７／２７）（ＭＣＰＥＮＴ法）；几何平均滴度（ＧＭＴ）为８．４、３．２、１７．０５。通过１９９５年春峰及秋冬峰本病高峰期观察，接种人群未发生病人，对照人群发病２５例，发病率２１０．９／１０万，疫苗保护率１００％，疫苗接种无明显不良反应，安全性较好，近期免疫、防病效果较理想。
This article reports the immunogenicity of Hemorrhagic Fever with Type 2 Haemorrhagic Fever with Renal Cell Inactivated Vaccine in Shandong Province. The positive rates of serum neutralizing antibody in 12 months after vaccination were 2 weeks and 3 weeks after vaccination, respectively. The positive rates of serum neutralizing antibody in the 12 months after vaccination were 68.96% (20/29) and 18.5% (5/27), respectively And antibody positive rate of 100% (27/27) (MCPENT method); geometric mean titer (GMT) was 8.4,3.2,17.05. Through the peak of the peak in spring peak and autumn and winter peak in 1995, there were 25 cases inoculated with no incidence of the disease in the control group, the incidence rate was 210.9 / 100000, the vaccine protection rate was 100%, the vaccination had no obvious adverse reactions, and the safety was better Good, recent immunization, disease prevention is better.