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目的探讨笑气联合米索前列醇、利多卡因和单用笑气时在人工流产中的镇痛作用及宫颈松弛程序等临床疗效。方法将400例孕40~70 d早孕妇女随机分为观察组和对照组各200例。观察组术前1 h舌下含化米索前列醇片200μg,术前半小时肌内注射阿托品0.5 mg,术中吸入笑气,并于宫颈注射1%利多卡因5 ml。对照组仅在术前30 min肌内注射阿托品0.5 mg,术中吸入笑气。结果观察组镇痛效果达无痛、宫颈松弛及术后宫缩痛缓解时间与结照组比较差异均有非常显著性(P<0.01)。不良反应发生率无差异(P>0.05)。结论笑气联合米索前列醇、利多卡因用于人工流产术中镇痛安全,效果满意,有协同作用,比单用笑气效果更好。
Objective To investigate the analgesic effect of abortion combined with misoprostol, lidocaine and nitrous oxide in abortion and the clinical efficacy of cervical relaxation procedure. Methods 400 pregnant women with gestational age from 40 to 70 days were randomly divided into observation group (200 cases) and control group (200 cases). The observation group received 200 μg of misoprostol misoprostol 1 h preoperatively and 0.5 mg of atropine 0.5 h intramuscularly before surgery, 5 ml of 1% lidocaine was injected into the cervix. The control group received intramuscular injection of atropine 0.5 mg intramuscularly only 30 min before operation, and niacin was inhaled intraoperatively. Results The analgesic effect of the observation group was painless, cervical relaxation and postoperative pain relief time were significantly different from those of the control group (P <0.01). There was no difference in the incidence of adverse reactions (P> 0.05). Conclusions Noxious combination of misoprostol and lidocaine for analgesia in induced abortion has satisfactory effect and synergistic effect, which is better than that of nitrous oxide alone.