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目的:观察益气活血法四妙通脉汤防治大鼠下肢DVT疗效。方法:SD大鼠80只,随机分为4组。A组20只,造模后四妙通脉汤灌胃给药;B组20只,造模后每日肌肉注射低分子肝素钠;C组20只,只结扎,不给药;D组20只,开腹后不结扎,不给药。结果:四妙通脉汤能减轻大鼠下肢肿痛,改善大鼠的一般状态。用药7d,A、B、C组D-D和PT时间均下降,A、B两组与C组比较差异有统计学意义(P<0.01),A、B两组之间比较差异无统计学意义(P>0.05);A组电镜下仅1只为不完全性血栓,血栓发生率5%;B组电镜下1只静脉为完全性血栓,发生率5%;C组15只为完全性血栓,5只为不完全性血栓,血栓发生率100%;D组20只,静脉无血栓。结论:益气活血方药四妙通脉汤对深静脉血栓的防治有较好疗效,能改善下肢肿痛,具有抗凝聚、提高纤溶活性的作用。
Objective: To observe the curative effect of Si Miaotongmai Decoction of Yiqi Huoxue Decoction on lower extremity DVT in rats. Methods: 80 SD rats were randomly divided into 4 groups. 20 rats in group A were intragastrically administrated with Si Miaotongmai Decoction after modeling; 20 rats in group B were intramuscularly injected with low molecular weight heparin sodium after modeling; 20 rats in group C were only given ligation without administration; Group D 20 Only, after open laparotomy, do not give medicine. Results: Si Miaomongmai Decoction can relieve the swelling and pain of lower extremities in rats and improve the general state of rats. On the 7th day of treatment, the DD and PT time of group A, B and C decreased, while the difference between group A and group B was statistically significant (P <0.01). There was no significant difference between group A and group B P> 0.05). In group A, only 1 was incomplete thrombus and 5% thrombosis under electron microscopy. One vein was complete thrombus in group B with a rate of 5% 5 were incomplete thrombosis, the incidence of thrombosis 100%; D group 20, no thrombosis of the vein. Conclusion: Si Miao Tongmai Decoction of Yiqi Huoxue Recipe has good curative effect on the prevention and treatment of deep venous thrombosis, can improve the swelling and pain of lower extremity, has the effect of anticoagulant aggregation and fibrinolytic activity.