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单核细胞趋化蛋白-1(MCP-1)是CC类细胞趋化因子,对单核/巨噬细胞(Mο/Mφ)具有特异性趋化激活作用,参与了IgA肾病的炎症过程。本文对MCP-1及其受体CCR2的结构和功能以及在IgA肾病的发生发展中的作用、针对MCP-1的干预进行综述。
Monocyte chemoattractant protein-1 (MCP-1) is a CC-type chemokine that has specific chemotactic activation on monocytes / macrophages (Mο / Mφ) and is involved in the inflammatory process of IgA nephropathy. In this paper, the structure and function of MCP-1 and its receptor CCR2 as well as the role in the occurrence and development of IgA nephropathy were reviewed, and the intervention of MCP-1 was reviewed.