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目的观察急性心肌梗死(AMI)病人血N末端前脑利钠肽(NT-proBNP)水平及经皮冠状动脉介入治疗(PCI)前后NT-proBNP的改变。方法随机分为进行药物治疗(药物组)63例,行PCI治疗(PCI组)29例,采用免疫荧光法分别检测AMI病人及药物治疗组,PCI治疗组治疗后2周NT-proBNP水平。结果 AMI病人NT-proBNP明显高于正常,且与Killip分级有相关性。PCI治疗组NT-proBNP下降明显,差异有统计学意义(P<0.01)。结论 AMI患者经PCI治疗后,血浆NT-proBNP水平改善,说明PCI术后供血改善,心功能也同样改善。
Objective To observe the level of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with acute myocardial infarction (AMI) and the changes of NT-proBNP before and after percutaneous coronary intervention (PCI). Methods Thirty-six patients were randomly divided into medical treatment group (PCI group) and PCI group (29 cases). The levels of NT-proBNP in the AMI patients and the drug-treated group and the PCI group were detected by immunofluorescence. Results The NT-proBNP in patients with AMI was significantly higher than normal and correlated with Killip classification. NT-proBNP decreased significantly in PCI group, with significant difference (P <0.01). Conclusion The improvement of plasma NT-proBNP level after PCI in AMI patients shows that the blood supply after PCI is improved and the heart function is also improved.