血管内皮生长因子(VEGF)等和内皮抑素(En-dostatin)作用于血管内皮细胞,两者间的平衡决定了血管的生长或抑制。在肿瘤生长过程中,存在持续而失控的血管生成。1971年,Folkman[1]首次提出肿瘤生长和转移依赖血管生成。因此,抑制肿瘤血管生成,促使肿瘤细胞进入休眠状态或诱发凋亡 Vascular endothelial growth factor (VEGF) and so on and endostatin (En-dostatin) in vascular endothelial cells, the balance between the decision of the growth or inhibition of blood vessels. During tumor growth, there is ongoing and uncontrolled angiogenesis. In 1971, Folkman [1] first proposed that tumor growth and metastasis depend on angiogenesis. Therefore, inhibition of tumor angiogenesis, prompting tumor cells into the dormant state or induce apoptosis