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~(19)F磁共振成像(MRI)的研究可追溯到30多年前。在这30多年间,氢原子核(~1H)成像技术迅速发展,并在全球得到广泛应用,使得磁共振成像成为生物医学诊断成像技术中不可缺少的支柱。多年来,由于各种原因,对~(19)F成像技术的研究进展缓慢。但是在过去的十年间,尤其是最近几年,~(19)F成像的研究和临床相关性呈爆发式发展。部分原因归结为MRI仪器、~(19)F/~1H线圈设计以及临床前和临床核磁共振仪的超高速脉冲序列的发展。这些成就再加上对解剖生理学分子成像技术的兴趣以及一批创新造影剂的出现使~(19)F的概念进入了早期的临床评估中。本篇综述重点探讨以液态全氟化碳化合物为基础的造影剂,并试图呈现这段丰富的研究和发展历史。
~ (19) F Magnetic resonance imaging (MRI) research dates back more than 30 years. During these 30 years, the rapid development of hydrogen nuclei (~ 1H) imaging technology and its wide application in the world have made magnetic resonance imaging an indispensable pillar in biomedical diagnostic imaging. For many years, research on ~ (19) F imaging has progressed slowly for a variety of reasons. However, in the past decade, especially in recent years, the research and clinical relevance of ~ (19) F imaging have been exploding. Part of the reason comes down to the development of MRI instrumentation, ~ (19) F / ~ 1H coil design, and ultra-high speed pulse sequences in preclinical and clinical NMR. These achievements, coupled with interest in anatomical molecular imaging techniques and the advent of a number of innovative contrast agents, have led to the concept of 19F into early clinical evaluation. This review focuses on liquid perfluorocarbon-based contrast media and attempts to present this rich history of research and development.