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利用羧甲基纤维素钠和聚乙烯醇－１２４为载体，甲硝唑为主药制成一种可吸收性牙周炎缓释药膜。此药膜可贴、口含和插入牙周袋内，观察药膜体外释放试验及临床应用。结果显示，体外释放缓慢。２０２例牙周炎患者的牙龈炎指数（ＧＩ）、龈沟出血指数（ＳＢＩ）、牙周袋深度（ＰＰＤ）明显下降，显效９０．１０％，有效７．９２％，无效１．９８％。
The use of sodium carboxymethyl cellulose and polyvinyl alcohol -124 carrier, metronidazole as the main drug to produce a sustained-release drug-resistant periodontitis membrane. The film can be affixed to the mouth and inserted into the periodontal pocket to observe the drug release test in vitro and clinical application. The results showed slow release in vitro. Gingivitis index (GI), sulcus bleeding index (SBI) and periodontal pocket depth (PPD) were significantly decreased in 202 patients with periodontitis, with a marked improvement of 90.10%, effective 7.92% and ineffective 1.98%.