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目的探讨影响住院T2DM患者左心室舒张功能不全(LVDD)的相关因素。方法连续收集1013例住院T2DM患者的临床资料,采用超声心动图检测左心室舒张功能。Logistic回归分析LVDD的影响因素。结果 51.3%的患者存在LVDD。LVDD组较非LVDD组年龄[(49.0±12.1)vs(61.3±10.0)岁]、中位糖尿病病程(7.0 vs 11.0年)、WC[(93.6±11.0)vs(95.4±10.7)cm]、SBP[(128±16)vs(134±18)mmHg]、Cr[(61.4±15.7)vs(68.0±30.0)μmol/L]、尿白蛋白/肌酐(UAlb/Cr)(4.3vs6.2 mg/g)升高(P<0.05);Logistic回归分析显示,年龄、WC、SBP、LDL-C、Cr与LVDD独立相关[OR(95%CI):1.110(1.091~1.129)、1.023(1.007~1.039)、1.013(1.004~1.022)、1.264(1.052~1.519)、1.010(1.001~1.020),P<0.05];在无高血压史患者中,随HbA_1 c增高,LVDD患病风险增高,但差异无统计学意义(P=0.055)。结论住院T2DM患者中,LVDD患病率高,年龄、WC、SBP、LDL-C和Cr增高与LVDD独立相关。
Objective To investigate the influencing factors of left ventricular diastolic dysfunction (LVDD) in hospitalized patients with T2DM. Methods The clinical data of 1013 inpatients with T2DM were collected continuously and the left ventricular diastolic function was measured by echocardiography. Logistic regression analysis of influential factors of LVDD. Results 51.3% of patients had LVDD. LVDD group had significantly lower SBP (median age ranged from 49.0 ± 12.1 vs 61.3 ± 10.0 years), median duration of diabetes (7.0 vs 11.0 years), WC [(93.6 ± 11.0) vs (95.4 ± 10.7) (128 ± 16 vs 134 ± 18 mmHg), Cr (61.4 ± 15.7 vs 68.0 ± 30.0 μmol / L) and UAb / Cr (4.3 vs 6.2 mg / (95% CI): 1.110 (1.091 ~ 1.129), 1.023 (1.007 ~ 1.039) in patients with LVDD and age, WC, SBP, LDL- ), 1.013 (1.004-1.022), 1.264 (1.052-1.519), 1.010 (1.001-1.020), respectively, P <0.05]. In patients with no history of hypertension, the risk of LVDD increased with the increase of HbA 1 c, but no difference Statistical significance (P = 0.055). Conclusions The prevalence of LVDD, age, WC, SBP, LDL-C and Cr in hospitalized patients with T2DM are independently associated with LVDD.