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目的通过比较检测幽门螺旋杆菌(Hp)的两种方法,探讨幽门螺旋杆菌IgG抗体及13 C-尿素呼气试验在健康查体人员中的临床应用价值,了解健康查体人员感染Hp的现状。方法健康查体人员310名,抽取静脉血3mL用于幽门螺旋杆菌IgG抗体检测,同时用13 C-尿素呼气试验通过吹气方法检测Hp感染,并对两种方法检测结果进行统计学分析。结果幽门螺旋杆菌IgG抗体测定阳性总数为161例,阳性率为51.9%;13 C-尿素呼气试验测定阳性总数为156例,阳性率为50.3%,二者差异无统计学意义(P>0.05)。结论鉴于目前健康人群中Hp的感染率较高,且Hp是慢性胃炎、胃和十二指肠溃疡、消化性胃黏膜相关的淋巴样组织淋巴瘤和胃腺癌等的危险因素,因而Hp的检测应作为常规体检项目。通过比较幽门螺旋杆菌IgG抗体及13 C-尿素呼气试验两种检测方法,幽门螺旋杆菌IgG抗体的检测方法更适合各级医院大规模查体的需要,具有较高的临床应用价值。
Objective To investigate the clinical value of Helicobacter pylori (IgG) antibody and 13 C-urea breath test in healthy people by comparing two methods to detect Helicobacter pylori (Hp) and find out the status of Hp infection among healthy people. Methods A total of 310 healthy people were enrolled in this study. Venous blood was drawn from 3 mL for the detection of H. pylori IgG antibody. Hp infection was detected by air-blowing method with 13 C-urea breath test, and the results of two methods were statistically analyzed. Results The total number of positive H. pylori IgG antibodies was 161 and the positive rate was 51.9%. The positive rate of 13 C-urea breath test was 156 and the positive rate was 50.3%, with no significant difference (P> 0.05 ). Conclusions In view of the current high prevalence of Hp in healthy people and the fact that Hp is a risk factor for chronic gastritis, gastric and duodenal ulcers, gastric mucosa-associated lymphoid tissue lymphoma, and gastric adenocarcinoma, detection of Hp Should be used as a regular physical examination. By comparing H. pylori IgG antibody and 13 C-urea breath test two detection methods, detection of Helicobacter pylori IgG antibody is more suitable for large-scale physical examination of hospitals at all levels, with high clinical value.