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应用中草药治疗丙型肝炎报道较多,然而这些研究大多采用中药复方制剂进行临床治疗,疗效局限。由于一种中药含有多种活性物质,某些物质之间在体内甚至有相互拮抗的作用,因此,对于治疗结果的作用机理很难阐述清楚。简述了HCV假病毒、复制子和全长细胞培养系统的研究现状,并对应用HCV RNA细胞模型研究中药单体或有效成分进行抗HCV实验研究的相关进展进行了综述,为中药治疗丙型肝炎研究提供新思路。
Chinese herbal medicine treatment of hepatitis C reported more, but most of these studies using traditional Chinese medicine compound preparation for clinical treatment, curative effect is limited. Since a traditional Chinese medicine contains many active substances and some substances even antagonize each other in vivo, it is very difficult to clarify the mechanism of action of the therapeutic result. The current research status of HCV pseudovirus, replicon and full-length cell culture system was briefly reviewed. The progress of anti-HCV experiment using Chinese traditional medicine monomer or active ingredient by HCV RNA cell model was reviewed. Hepatitis research provides new ideas.